102634-23-1

102634-23-1 structure

Name: Lamprey LH-RH I
Chemical Name: lamprey gonadotropin-releasing hormone
CAS Number: 102634-23-1
Molecular Formula: C₅₈H₇₉N₁₅O₁₅
Molecular Weight: 1226.34000
Catalog: Signaling Pathways GPCR/G Protein GNRH Receptor
Create Date: 2018-03-03 09:39:36
Modify Date: 2024-01-10 23:59:01
Lamprey LH-RH I is a gonadotropin-releasing hormone, elevates plasma steroid levels and stimulates ovulation in the lamprey without biological activity in other animal models[1].

Name	lamprey gonadotropin-releasing hormone

Description	Lamprey LH-RH I is a gonadotropin-releasing hormone, elevates plasma steroid levels and stimulates ovulation in the lamprey without biological activity in other animal models[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GNRH Receptor Research Areas >> Endocrinology
In Vitro	Lamprey LH-RH I has a primary mechanism of transport to the pituitary is simple diffusion from neuronal terminals in the neurohypophysis to the adenohypophysis. An additional route is via secretion into the third ventricle and transport by tanycytes to the adenohypophysis[2].
In Vivo	Lamprey LH-RH I (5-200 μg/kg; i.p.; single dose or twice) elevates plasma steroid levels and stimulates lamprey ovulation[1]. Animal Model: Female sea-run sea lampreys[1] Dosage: 5 μg/kg, 50 μg/kg, 100 μg/kg, 200 μg/kg; dissolved in 0.6% NaCl in distilled water Administration: Intraperitoneal injection; single dose or twice; observed for 30 days Result: Significantly increased estradiol in a dose-related manner. Resulted 80% of the lampreys ovulation at 200 or 100 μg/kg compared in a doserelated manner.