125720-84-5
125720-84-5 structure
- Name: (E)-Alprenoxime
- Chemical Name: 1-(2-Allyl-phenoxy)-3-isopropylamino-propan-2-one oxime
- CAS Number: 125720-84-5
- Molecular Formula: C15H22N2O2
- Molecular Weight: 262.34700
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2018-05-23 05:48:22
- Modify Date: 2024-01-19 15:05:22
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(E)-Alprenoxime is the isomer of the Alprenoxime. Alprenoxime is a site-activated ocular β-blocker.
| Name | 1-(2-Allyl-phenoxy)-3-isopropylamino-propan-2-one oxime |
|---|---|
| Synonyms | (E)-Alprenoxime |
| Description | (E)-Alprenoxime is the isomer of the Alprenoxime. Alprenoxime is a site-activated ocular β-blocker. |
|---|---|
| Related Catalog | |
| Target |
β blocker[1] |
| In Vivo | The purpose of the present study is to explore the pharmacological significance of Alprenoxime peripheral /βblocking activity in a non-rodent animal model. Interspecies scaling considerations predict that the doses selected in this study (1 and 5 mg/kg) are pharmacologically comparable or greater than doses used in rodent studies (2 and 6 mg/kg). More importantly, the prolonged ocular antihypertensive effects that are shown with 1% ophthalmic solutions indicate that the i.v. dose tested in the present study is likely to be more than two orders of magnitude greater than probable therapeutic doses[1]. |
| Animal Admin | Dogs[1] Seven adult mongrel dogs (20-27 kg) are used in this study. A loading dose of Alprenoxime is administered (1 mg/kg, i.v.) followed by Alprenoxime infusion (150 μg/kg/min) after recording baseline electrophysiological parameters. Cardiac electrophysiological testing is then repeated 10 min after beginning Alprenoxime infusion. Alprenoxime (1 or 5 mg/kg, i.v.) is injected as a bolus injection and cardiac electrophysiological response is monitored. Different dogs with isoproterenol induced tachycardia are evaluated at each Alprenoxime dose. |
| References |
| Molecular Formula | C15H22N2O2 |
|---|---|
| Molecular Weight | 262.34700 |
| Exact Mass | 262.16800 |
| PSA | 53.85000 |
| LogP | 3.01300 |