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Product Name: ACPT-II
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195209-04-2

195209-04-2 structure

195209-04-2 structure

Name: ACPT-II
Chemical Name: acpt-ii
CAS Number: 195209-04-2
Molecular Formula: C₈H₁₁NO₆
Molecular Weight: 217.18
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2017-12-24 15:27:29
Modify Date: 2025-08-21 16:21:53
ACPT-II is an agonist of group III mGluRs with diverse biological activities including neuroprotective, anticonvulsant, and anxiolytic-like effects[1][2][3][4][5].

Name	acpt-ii

Description	ACPT-II is an agonist of group III mGluRs with diverse biological activities including neuroprotective, anticonvulsant, and anxiolytic-like effects[1][2][3][4][5].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
References	[1]. Acher FC, et al. Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J Med Chem. 1997 Sep 12;40(19):3119-29. [2]. Domin H, et al. Neuroprotective potential of the group III mGlu receptor agonist ACPT-I in animal models of ischemic stroke: In vitro and in vivo studies. Neuropharmacology. 2016 Mar;102:276-94. [3]. Domin H, et al. Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo. Neurotox Res. 2014 Jul;26(1):99-113. [4]. Chapman AG, et al. Anticonvulsant activity of a mGlu(4alpha) receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid. Eur J Pharmacol. 2001 Jul 20;424(2):107-13. [5]. Stachowicz K, et al. The group III mGlu receptor agonist ACPT-I exerts anxiolytic-like but not antidepressant-like effects, mediated by the serotonergic and GABA-ergic systems. Neuropharmacology. 2009 Sep;57(3):227-34.

Molecular Formula	C₈H₁₁NO₆
Molecular Weight	217.18
Exact Mass	217.05900
PSA	137.92000

194918-80-4 structure

194918-80-4

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195209-04-2 structure

195209-04-2

Literature: Acher, Francine C.; Tellier, Frederique J.; Azerad, Robert; Brabet, Isabelle N.; Fagni, Laurent; Pin, Jean R. Journal of Medicinal Chemistry, 1997 , vol. 40, # 19 p. 3119 - 3129

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