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133550-49-9

133550-49-9 structure
133550-49-9 structure
  • Name: Tyrphostin AG 528
  • Chemical Name: Tyrphostin AG 528
  • CAS Number: 133550-49-9
  • Molecular Formula: C18H14N2O3
  • Molecular Weight: 306.31500
  • Catalog: Research Areas Cancer
  • Create Date: 2018-01-08 00:12:34
  • Modify Date: 2024-05-01 19:00:31
  • Tyrphostin AG 528 is an inhibitor of EGFR and ErbB2 with IC50s of 4.9 and 2.1 μM, respectively.

Name Tyrphostin AG 528
Synonyms N-(3',4'-dihydroxybenzylidenecyanoacetyl)indoline
(E)-2-(2,3-Dihydro-indole-1-carbonyl)-3-(3,4-dihydroxy-phenyl)-acrylonitrile
Description Tyrphostin AG 528 is an inhibitor of EGFR and ErbB2 with IC50s of 4.9 and 2.1 μM, respectively.
Related Catalog
Target

EGFR:4.9 μM (IC50)

ErbB2:2.1 μM (IC50)

References

[1]. Naijue Zhu, et al. Tyrphostin Tumor Growth Inhibitors of EGFR and ErbB2 Tyrosine Kinase. J Chem Crystallogr. 2007, 37, 679–683.

Melting Point 215 °C
Molecular Formula C18H14N2O3
Molecular Weight 306.31500
Exact Mass 306.10000
PSA 84.56000
LogP 2.65908
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport