40533-25-3
40533-25-3 structure
- Name: Cyclapolin 9
- Chemical Name: Cyclapolin 9
- CAS Number: 40533-25-3
- Molecular Formula: C9H4F3N3O4S
- Molecular Weight: 307.20600
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Polo-like Kinase (PLK)
- Create Date: 2017-10-01 10:52:37
- Modify Date: 2024-01-09 13:09:28
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Cyclapolin 9 is a potent, selective and ATP-competitive polo-like kinase 1 (PLK1) inhibitor with an IC50 of 500 nM. Cyclapolin 9 is inactive against other kinases[1][2].
| Name | Cyclapolin 9 |
|---|---|
| Synonyms |
5-methylpyridazinecarboxamide 4-oxide
5-methyl-pyrazin-2-carboxamide-4-oxide 2-carbamoyl-5-methylpyrazine 4-oxide Pyrazinecarboxamide,5-methyl-,4-oxide 7-nitro-3-oxy-5-trifluoromethyl-benzothiazole-2-carboxylic acid amide L-NMMA acetate 5-methyl-pyrazine-2-carboxamide-4-oxide 2-Carbamoyl-5-methylpyrazin-4-oxid 5-methyl-4-oxy-pyrazine-2-carboxylic acid amide 2-Carbamoyl-7-nitro-5-trifluormethyl-benzothiazole-N-oxide |
| Description | Cyclapolin 9 is a potent, selective and ATP-competitive polo-like kinase 1 (PLK1) inhibitor with an IC50 of 500 nM. Cyclapolin 9 is inactive against other kinases[1][2]. |
|---|---|
| Related Catalog | |
| Target |
PLK1:500 nM (IC50) |
| In Vitro | Cyclapolin 9 (3 μM) reduces electric field stimulation (EFS)-induced contractions of prostate strips. The α1-adrenergic smooth muscle contraction in the human prostate can be inhibited by Cyclapolin 9[1]. |
| References |
| Molecular Formula | C9H4F3N3O4S |
|---|---|
| Molecular Weight | 307.20600 |
| Exact Mass | 306.98700 |
| PSA | 142.61000 |
| LogP | 3.57920 |
| HS Code | 2934999090 |
|---|
|
~%
40533-25-3 |
| Literature: CYCLACEL LIMITED Patent: WO2004/67000 A1, 2004 ; Location in patent: Page/Page column 25-26 ; WO 2004/067000 A1 |
| Precursor 1 | |
|---|---|
| DownStream 0 | |
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |