10500-64-8

10500-64-8 structure

Name: Hydroxychloroquine Impurity E
Chemical Name: 4-[(7-chloroquinolin-4-yl)amino]pentan-1-ol
CAS Number: 10500-64-8
Molecular Formula: C₁₄H₁₇ClN₂O
Molecular Weight: 264.75100
Catalog: Research Areas Others
Create Date: 2017-04-14 04:08:05
Modify Date: 2024-01-03 23:23:10
Hydroxychloroquine Impurity E is the impurity of Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3].

Name	4-[(7-chloroquinolin-4-yl)amino]pentan-1-ol
Synonyms	GNF-Pf-1978 4-[(7-Chloro-4-quinolinyl)amino]-1-pentanol Plaquenil Impurity 1

Description	Hydroxychloroquine Impurity E is the impurity of Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4(1):6. [2]. Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40. [3]. Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Mar 9. pii: ciaa237.

HS Code	2933499090

86-98-6

10500-64-8

Literature: Journal of the American Chemical Society, , vol. 68, p. 1224

Precursor 1
86-98-6
DownStream 0

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%