54676-54-9

54676-54-9 structure

Name: (Z)-p-cyano-α-Cyanostilbene
Chemical Name: (Z)-4-(1-cyano-2-phenylvinyl)benzonitrile
CAS Number: 54676-54-9
Molecular Formula: C₁₆H₁₀N₂
Molecular Weight: 230.26
Catalog: Research Areas Cancer
Create Date: 2018-03-10 06:18:51
Modify Date: 2024-04-03 12:50:34
(Z)-p-cyano-α-Cyanostilbene (compound 11), a phenantrene derivative, has antiproliferative activity. (Z)-p-cyano-α-Cyanostilbene shows significant selectivity against HeLa (IC50=0.21 µM) and HepG2 (IC50=0.230 µM) cells without cytotoxic against normal skin fibroblasts (IC50>100 µM)[1].

Name	(Z)-4-(1-cyano-2-phenylvinyl)benzonitrile
Synonyms	4-(1-cyano-2-phenylvinyl)benzonitrile 4-((Z)-1-Cyano-2-phenyl-vinyl)-benzonitrile

Description	(Z)-p-cyano-α-Cyanostilbene (compound 11), a phenantrene derivative, has antiproliferative activity. (Z)-p-cyano-α-Cyanostilbene shows significant selectivity against HeLa (IC50=0.21 µM) and HepG2 (IC50=0.230 µM) cells without cytotoxic against normal skin fibroblasts (IC50>100 µM)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Nataša Perin, et al. Antiproliferative activity and mode of action analysis of novel amino and amido substituted phenantrene and naphtho[2,1-b]thiophene derivatives. Eur J Med Chem. 2020 Jan 1;185:111833.