1092540-56-1

1092540-56-1 structure

Name: CTP 518(Atazanavir, deuterated)
Chemical Name: trideuteriomethyl N-[(2S)-1-[2-[(2S,3S)-2-hydroxy-4-phenyl-3-[[(2S)-4,4,4-trideuterio-2-(trideuteriomethoxycarbonylamino)-3,3-bis(trideuteriomethyl)butanoyl]amino]butyl]-2-[(4-pyridin-2-ylphenyl)methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate
CAS Number: 1092540-56-1
Molecular Formula: C₃₈H₃₇D₁₅N₆O₇
Molecular Weight: 719.95
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2018-06-12 08:09:16
Modify Date: 2024-01-17 20:38:12
Atazanavir-d15 is the d15 labled Atazanavir (HY-17367). Atazanavir is a selective HIV-1 protease inhibitor[1].

Name	trideuteriomethyl N-[(2S)-1-[2-[(2S,3S)-2-hydroxy-4-phenyl-3-[[(2S)-4,4,4-trideuterio-2-(trideuteriomethoxycarbonylamino)-3,3-bis(trideuteriomethyl)butanoyl]amino]butyl]-2-[(4-pyridin-2-ylphenyl)methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate
Synonyms	(H)Methyl [(5S,10S,11S,14S)-11-benzyl-10-hydroxy-15,15-bis[(H)methyl]-5-(2-methyl-2-propanyl)-3,6,13-trioxo-8-[4-(2-pyridinyl)benzyl](1,1,1,16,16,16-H)-2-oxa-4,7,8,12-tetraazahexadec an-14-yl]carbamate Butanoic acid, 3,3-dimethyl-2-[[(methyl-d-oxy)carbonyl]amino]-, 2-[(2S,3S)-3-[[(2S)-3,3-di(methyl-d)-2-[[(methyl-d-oxy)carbonyl]amino]-1-oxobutyl-4,4,4-d]amino]-2-hydroxy-4-phenylbutyl]-2- [[4-(2-pyridinyl)phenyl]methyl]hydrazide, (2S)- y0306

Description	Atazanavir-d15 is the d15 labled Atazanavir (HY-17367). Atazanavir is a selective HIV-1 protease inhibitor[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV-1
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.