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  • DC Chemicals Limited
  • China
  • Product Name: Dup-721
  • Price: ¥Inquiry/100mg ¥Inquiry/250mg ¥Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Tony Cao

104421-21-8

104421-21-8 structure
104421-21-8 structure
  • Name: Dup-721
  • Chemical Name: N-[(S)-3-(4-Acetyl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide
  • CAS Number: 104421-21-8
  • Molecular Formula: C14H16N2O4
  • Molecular Weight: 276.29
  • Catalog: Signaling Pathways Anti-infection Bacterial
  • Create Date: 2018-03-02 06:27:11
  • Modify Date: 2024-01-11 00:23:50
  • DuP-721 is a broad spectrum and orally active antibacterial agent against a variety of clinically susceptible and resistant bacteria, especially M. tuberculosis[1].

Name N-[(S)-3-(4-Acetyl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide
Synonyms DuP 721
Dup-721
Description DuP-721 is a broad spectrum and orally active antibacterial agent against a variety of clinically susceptible and resistant bacteria, especially M. tuberculosis[1].
Related Catalog
In Vitro DuP-721 (1.5-4 μg/ml) inhibits equally the strains of Mycobacterium tuberculosis susceptible and resistant to conventional antituberculosis drug. And it does not show cross resistance to any of the anti-tuberculosis drugs tested[1]. DuP-721 is inactive against M. avium and M. intracellulare at 250 μg/ml. It inhibits M. gordonoe and M. fortuitum at 3.9 μg/ml and M. kansassi and M. scrofulaceum at 1.95 μg/ml and 15.6 μg/ml, respectively[1].
In Vivo DuP-721 (oral gavage; 50-160 mg/kg) is protective against M. tuberculosis infection in mice. DuP-721 protects 100% of the infected animals at 50 mg/kg p.o. dose when administered daily for 17 days, and the same effect is observed at 160 mg/kg dose when the drug is administered only on day 11 and 12 post infection[1].
References

[1]. Affiliatio, et al. Antimycobacterial activities of oxazolidinones: a review. Infect Disord Drug Targets. 2006 Dec;6(4):343-54.

Molecular Formula C14H16N2O4
Molecular Weight 276.29
Exact Mass 276.11100
PSA 75.71000
LogP 1.80640