64095-60-9
64095-60-9 structure
- Name: LONGISTYLINE A
- Chemical Name: (E)-3-methoxy-2-(3-methylbut-2-enyl)-5-styryl-phenol
- CAS Number: 64095-60-9
- Molecular Formula: C20H22O2
- Molecular Weight: 294.38700
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2018-06-02 09:32:55
- Modify Date: 2024-01-10 19:25:07
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Longistyline A (Longistylin A) is a natural stilbene, it can be isolated from leaves of Cajanus cajan. Longistyline A shows antimicrobial activity against MRSA with an MIC value of 1.56 μg/mL. Longistyline A shows neuroprotective effects, it can be used for the research of infection and nerve diseases[1][2].
| Name | (E)-3-methoxy-2-(3-methylbut-2-enyl)-5-styryl-phenol |
|---|---|
| Synonyms |
longistylin A
Longstylin A cajanine A longistyline A 3-Methoxy-2-(3-methyl-but-2-enyl)-5-((E)-styryl)-phenol |
| Description | Longistyline A (Longistylin A) is a natural stilbene, it can be isolated from leaves of Cajanus cajan. Longistyline A shows antimicrobial activity against MRSA with an MIC value of 1.56 μg/mL. Longistyline A shows neuroprotective effects, it can be used for the research of infection and nerve diseases[1][2]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 8.61 μg/mL (murine RAW264.7 cells)[2] |
| In Vitro | Longistyline A (4-16 μM/L; 48 h) reduces the corticosterone-induced neurotoxicity in PC12 cells[1]. Longistyline A can function as a membrane-targeting antibacterial agent by disturbing bacterial membrane potential and increasing the permeation[2]. Longistyline A (0-100 μg/mL) shows significant antimicrobial activity against tested Gram-positive bacteria, such as B.cereus CMCC63302 with MIC values of 25 μg/mL, S.aureus CMCC26003 with MIC values of 1.56 μg/mL, and both two strains of MRSA (JCSC4744 and JCSC4469) with MIC values of 1.56 μg/mL[2]. Longistyline A (24 h) shows cytotoxicity towards murine RAW264.7 cells with an IC50 value of 8.61 μg/mL[2]. Cell Cytotoxicity Assay[1] Cell Line: PC12 cell line Concentration: 4, 8 and 16 μM/L Incubation Time: 48 hours Result: Generated a neuroprotective effect against corticosterone-induced neurotoxicity in PC12 cells possibly by decreasing [Ca2+]i and caspase-3 activity. |
| In Vivo | Longistyline A (10 µg dissolved in 50 µL PBS buffer; apply to the wound; for 30 min) improves wound healing, decreases MRSA bacterial survivals in the lesions and reduces inflammatory reaction in MRSA infected mice[2]. Animal Model: Female wound healing BALB/c mice with MRSA infection[2] Dosage: 10 µg Administration: Apply to the wound; 10 µg dissolved in 50 µL PBS buffer; 5 min after infection for 30 min Result: Showed a wound healing efficiency and significantly alleviated weight loss induced by MRSA infection. Reduced gram-positive microorganisms in vivo with a better effect than vancomycin. Reduced accumulation of immune cells at the injury site and alleviated induction of TNF-α and IL-6 in serum. |
| Molecular Formula | C20H22O2 |
|---|---|
| Molecular Weight | 294.38700 |
| Exact Mass | 294.16200 |
| PSA | 29.46000 |
| LogP | 5.07990 |