419547-73-2

419547-73-2 structure

Name: Transketolase-IN-4
Chemical Name: 3-(4-chlorophenyl)-5-benzyl-4H-pyrazolo[1,5-a]pyrimidin-7-one
CAS Number: 419547-73-2
Molecular Formula: C₁₉H₁₄ClN₃O
Molecular Weight: 335.78700
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-01-07 11:43:10
Modify Date: 2024-02-02 00:35:58
Transketolase-IN-4 is a potent transketolase inhibitor (IC50=3.9 μM). Transketolase-IN-4 inhibits tumor cell proliferation of SW620, LS174T, and MIA PaCa-2. Transketolase-IN-4 is a possible Mycobacterium tuberculosis DXS inhibitor, with an IC50 value of 114.1 μM[1][2].

Name	3-(4-chlorophenyl)-5-benzyl-4H-pyrazolo[1,5-a]pyrimidin-7-one

Description	Transketolase-IN-4 is a potent transketolase inhibitor (IC50=3.9 μM). Transketolase-IN-4 inhibits tumor cell proliferation of SW620, LS174T, and MIA PaCa-2. Transketolase-IN-4 is a possible Mycobacterium tuberculosis DXS inhibitor, with an IC50 value of 114.1 μM[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 3.9 μM (Transketolase)[1]; 114.1 μM (Mycobacterium tuberculosis DXS)[2]
References	[1]. Du MX, et al. Identification of novel small-molecule inhibitors for human transketolase by high-throughput screening with fluorescent intensity (FLINT) assay. J Biomol Screen. 2004 Aug;9(5):427-33. [2]. Mao J, et al. Structure-activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5320-3.