1415558-82-5

1415558-82-5 structure

Name: 2-Keto Crizotinib
Chemical Name: 4-(4-{6-Amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-pyridinyl}-1H-pyrazol-1-yl)-2-piperidinone
CAS Number: 1415558-82-5
Molecular Formula: C₂₁H₂₀Cl₂FN₅O₂
Molecular Weight: 464.320
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK ALK
Create Date: 2018-04-19 09:31:44
Modify Date: 2024-01-11 13:53:16
2-Keto Crizotinib (PF-06260182) is an active lactam metabolite of crizotinib.

Name	4-(4-{6-Amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-pyridinyl}-1H-pyrazol-1-yl)-2-piperidinone
Synonyms	4-(4-{6-Amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-pyridinyl}-1H-pyrazol-1-yl)-2-piperidinone 4-(4-{6-Amino-5-[(1R)-1-(2,6-dichlor-3-fluorphenyl)ethoxy]-3-pyridinyl}-1H-pyrazol-1-yl)-2-piperidinon 2-Piperidinone, 4-[4-[6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-pyridinyl]-1H-pyrazol-1-yl]- 4-(4-{6-Amino-5-[(1R)-1-(2,6-dichloro-3-fluorophényl)éthoxy]-3-pyridinyl}-1H-pyrazol-1-yl)-2-pipéridinone

Description	2-Keto Crizotinib (PF-06260182) is an active lactam metabolite of crizotinib.
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK Research Areas >> Cancer
In Vitro	2-Keto Crizotinib (PF-06260182) is active and considerably less potent than crizotinib, and it is not thought to contribute significantly to the in vivo activity of crizotinib.
References	[1]. Balis FM, e al. First-dose and steady-state pharmacokinetics of orally administered crizotinib in children with solid tumors: a report on ADVL0912 from the Children's Oncology Group Phase 1/Pilot Consortium. Cancer Chemother Pharmacol. 2017 Jan;79(1):181-187.