1453097-13-6

1453097-13-6 structure

Name: HUHS015
Chemical Name: 4-Benzyl-3-methyl-1-(5-methyl-1H-benzimidazol-2-yl)-1H-pyrazol-5-ol
CAS Number: 1453097-13-6
Molecular Formula: C₁₉H₁₈N₄O
Molecular Weight: 318.372
Catalog: Research Areas Cancer
Create Date: 2018-06-17 17:17:21
Modify Date: 2024-01-20 17:41:53
HUHS015 is a potent PCA-1/ALKBH3 inhibitor both in vitro and in vivo. The bioavailability (BA) of HUHS015 was 7.2% in rats after oral administration. Continuously administering HUHS015 significantly suppressed the growth of DU145 cells, which are human hormone-independent prostate cancer cells, in a mouse xenograft model without untoward effects. [1]

Name	4-Benzyl-3-methyl-1-(5-methyl-1H-benzimidazol-2-yl)-1H-pyrazol-5-ol
Synonyms	1H-Pyrazol-5-ol, 3-methyl-1-(6-methyl-1H-benzimidazol-2-yl)-4-(phenylmethyl)- 4-Benzyl-3-méthyl-1-(6-méthyl-1H-benzimidazol-2-yl)-1H-pyrazol-5-ol 4-Benzyl-3-methyl-1-(6-methyl-1H-benzimidazol-2-yl)-1H-pyrazol-5-ol 4-Benzyl-3-methyl-1-(5-methyl-1H-benzimidazol-2-yl)-1H-pyrazol-5-ol 4-Benzyl-3-méthyl-1-(5-méthyl-1H-benzimidazol-2-yl)-1H-pyrazol-5-ol 1H-Pyrazol-5-ol, 3-methyl-1-(5-methyl-1H-benzimidazol-2-yl)-4-(phenylmethyl)- HUHS015

Description	HUHS015 is a potent PCA-1/ALKBH3 inhibitor both in vitro and in vivo. The bioavailability (BA) of HUHS015 was 7.2% in rats after oral administration. Continuously administering HUHS015 significantly suppressed the growth of DU145 cells, which are human hormone-independent prostate cancer cells, in a mouse xenograft model without untoward effects. [1]
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
References	[1]. Nakao S et al. Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs. Bioorg Med Chem Lett, 2014 Feb 15, 24(4):1071-4.