1821428-35-6
1821428-35-6 structure
- Name: AZD-0156
- Chemical Name: 8-{6-[3-(Dimethylamino)propoxy]-3-pyridinyl}-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one
- CAS Number: 1821428-35-6
- Molecular Formula: C26H31N5O3
- Molecular Weight: 461.556
- Catalog: Signaling Pathways Cell Cycle/DNA Damage ATM/ATR
- Create Date: 2018-01-05 04:45:18
- Modify Date: 2024-01-02 19:15:59
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AZD0156 is an oral, potent and selective ATM inhibitor with an IC50 of 0.58 nM.
| Name | 8-{6-[3-(Dimethylamino)propoxy]-3-pyridinyl}-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one |
|---|---|
| Synonyms |
8-{6-[3-(Dimethylamino)propoxy]-3-pyridinyl}-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-c]chinolin-2-on
2H-Imidazo[4,5-c]quinolin-2-one, 8-[6-[3-(dimethylamino)propoxy]-3-pyridinyl]-1,3-dihydro-3-methyl-1-(tetrahydro-2H-pyran-4-yl)- 8-{6-[3-(Dimethylamino)propoxy]-3-pyridinyl}-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one 8-{6-[3-(Diméthylamino)propoxy]-3-pyridinyl}-3-méthyl-1-(tétrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinoléin-2-one AZD-0156 AZD0156 |
| Description | AZD0156 is an oral, potent and selective ATM inhibitor with an IC50 of 0.58 nM. |
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| Related Catalog | |
| Target |
ATM |
| In Vitro | AZD0156 inhibits the kinase activity of ATM and ATM-mediated signaling, prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducs tumor cell apoptosis, and leads to cell death in ATM-overexpressing tumor cells[1]. |
| Cell Assay | HT29 cells are seeded into 384 well assay plates at a density of 6000 cells/well in 40 μL EMEM medium containing 1% L glutamine and 10% FBS and allowed to adhere overnight. The following morning compound of Formula (I) in 100% DMSO is added to assay plates by acoustic dispensing. After lh incubation at 37°C and 5% C02, 40 nL of 3 mM 4NQO in 100% DMSO is added to all wells by acoustic dispensing, except minimum control wells which are left untreated with 4NQO to generate a null response control. Plates are returned to the incubator for a further lh. Then cells are fixed by adding 20 μL of 3.7% formaldehyde in PBS solution and incubating for 20 mins at r.t.. Then 20 μL of 0.1% Triton XI 00 in PBS is added and incubated for 10 minutes at r.t., to permeabalise cells. Then the plates are washed once with 50 μL/well PBS, using a Biotek EL405 plate washer. |
| References |
[1]. Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer.? |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 628.3±55.0 °C at 760 mmHg |
| Molecular Formula | C26H31N5O3 |
| Molecular Weight | 461.556 |
| Flash Point | 333.8±31.5 °C |
| Exact Mass | 461.242676 |
| LogP | 2.40 |
| Appearance | white solid |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.626 |
| Storage condition | -20℃ |