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1360614-48-7

1360614-48-7 structure

1360614-48-7 structure

Name: Necrosulfonamide
Chemical Name: Necrosulfonamide
CAS Number: 1360614-48-7
Molecular Formula: C₁₈H₁₅N₅O₆S₂
Molecular Weight: 461.472
Catalog: Signaling Pathways MAPK/ERK Pathway Mixed Lineage Kinase
Create Date: 2018-03-30 22:07:10
Modify Date: 2026-07-01 23:54:30
Necrosulfonamide is a necroptosis inhibitor acting by selectively targeting the mixed lineage kinase domain-like protein (MLKL) to block the necrosome formation.

Name	Necrosulfonamide
Synonyms	(2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide (E)-N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide necrosulfonamide 2-Propenamide, N-[4-[[(3-methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-, (2E) (2E)-N-{4-[(3-Methoxy-2-pyrazinyl)sulfamoyl]phenyl}-3-(5-nitro-2-thienyl)acrylamide CHEBI:63770 NecrosulfonaMide formation,necrosis,necrosome,substrate,RIP3,Inhibitor,inhibit,complex,Necrosulfonamide,Mixed Lineage Kinase,MLKs (2Z)-N-{4-[(3-Methoxy-2-pyrazinyl)sulfamoyl]phenyl}-3-(5-nitro-2-thienyl)acrylamide (Z)-Necrosulfonamide Necrosulfonamide (NSA) (E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfaMoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylaMide (2E)-N-{4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl}-3-(5-nitrothiophen-2-yl)prop-2-enamide (E)-NECROSULFONAMIDE Necrosulfonamide, 10 mM in DMSO

Description	Necrosulfonamide is a necroptosis inhibitor acting by selectively targeting the mixed lineage kinase domain-like protein (MLKL) to block the necrosome formation.
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> Mixed Lineage Kinase Research Areas >> Cancer
References	[1]. Steinhart L et al. Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells andovercome apoptosis resistance by inducing necroptosis. Cell Death Dis. 2013 Sep 12; [2]. Sun L et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell. 2012 Jan 20;148(1-2):213-27. [3]. Dunai ZA et al. Staurosporine induces necroptotic cell death under caspase-compromised conditions in U937 cells. PLoS One. 2012;7(7): [4]. Bae JH et al. Chemical regulation of signaling pathways to programmed necrosis. Arch Pharm Res. 2014 Jun;37(6):689-97.

Density	1.6±0.1 g/cm3
Melting Point	257 °C(dec.)
Molecular Formula	C₁₈H₁₅N₅O₆S₂
Molecular Weight	461.472
Exact Mass	461.046387
LogP	4.08
Index of Refraction	1.695

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