188923-01-5

188923-01-5 structure

Name: L 760735
Chemical Name: 1-[5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-2H-triazol-4-yl]-N,N-dimethylmethanamine,hydrochloride
CAS Number: 188923-01-5
Molecular Formula: C₂₆H₂₉ClF₇N₅O₂
Molecular Weight: 611.98
Catalog: Signaling Pathways GPCR/G Protein Neurokinin Receptor
Create Date: 2016-06-08 18:03:00
Modify Date: 2024-01-09 09:43:27
L-760735 is a high affinity, selective and orally active NK1 receptor antagonist with an IC50 of 0.19 nM for human NK1 receptors. L-760735 exhibits anxiolytic and antidepressant-like effects[1].

Name	1-[5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-2H-triazol-4-yl]-N,N-dimethylmethanamine,hydrochloride

Description	L-760735 is a high affinity, selective and orally active NK1 receptor antagonist with an IC50 of 0.19 nM for human NK1 receptors. L-760735 exhibits anxiolytic and antidepressant-like effects[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
Target	hNK1:0.19 nM (IC50)
References	[1]. Harrison T, et al. An orally active, water-soluble neurokinin-1 receptor antagonist suitable for both intravenous and oral clinical administration. J Med Chem. 2001 Nov 22;44(24):4296-9.