145-39-1

145-39-1 structure

Name: Musk tibetene
Chemical Name: 1-tert-butyl-3,4,5-trimethyl-2,6-dinitrobenzene
CAS Number: 145-39-1
Molecular Formula: C₁₃H₁₈N₂O₄
Molecular Weight: 266.293
Catalog: Flavors and spices Synthetic spice Musk and macrocyclic spices Nitro musk
Create Date: 2018-08-10 11:16:24
Modify Date: 2024-01-09 18:13:38
Musk tibetene (Musk tibetine) is a nitro musk compound with carcinogenic activity. Musk tibetine reveals no genotoxicity in the micronucleus test with human lymphocytes and human hepatoma cell line[1][2].

Name	1-tert-butyl-3,4,5-trimethyl-2,6-dinitrobenzene
Synonyms	5-tert-Butyl-4,6-dinitro-1,2,3-trimethylbenzene 1-tert-butyl-4,3,5-trimethyl-2-amino-6-nitrobenzene 1,2,3-Trimethyl-5-(2-methyl-2-propanyl)-4,6-dinitrobenzene EINECS 205-651-6 Musk tibetine 1-tert-butyl-3,4,5-trimethyl-2,6-dinitro-benzene Musk tibetene Musk Tebetine Nitromusk tibetene 1-tert-Butyl-3,4,5-trimethyl-2,6-dinitrobenzene Benzene, 1- (1,1-dimethylethyl)-3,4,5-trimethyl-2,6-dinitro- 2-tert-Butyl-1,3-dinitro-4,5,6-trimethylbenzene Benzene, 1-(1,1-dimethylethyl)-3,4,5-trimethyl-2,6-dinitro- Tibetene musk 1-t-butyl-3,4,5-trimethyl-2,6-dinitrobenzene musk tibeten

Description	Musk tibetene (Musk tibetine) is a nitro musk compound with carcinogenic activity. Musk tibetine reveals no genotoxicity in the micronucleus test with human lymphocytes and human hepatoma cell line[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Musk tibetene reveals no genotoxicity in the micronucleus test with human lymphocytes and with the human hepatoma cell line Hep G2[1]. Musk tibetene reveals a cell-transforming potential that showed a dose-dependent response in our host-mediated assay system[2].
References	[1]. Kevekordes S, et al. Genotoxicity of nitro musks in the micronucleus test with human lymphocytes in vitro and the human hepatoma cell line Hep G2. Toxicol Lett. 1997 Mar 14;91(1):13-7. [2]. Apostolidis S, et al. Evaluation of carcinogenic potential of two nitro-musk derivatives, musk xylene and musk tibetene in a host-mediated in vivo/in vitro assay system. Anticancer Res. 2002 Sep-Oct;22(5):2657-62.

CHEMICAL NAME :: Benzene, 1-(1,1-dimethylethyl)-2,6-dinitro-3,4,5-trimethyl-

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,879,1975 ** ACUTE TOXICITY DATA **

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,879,1975

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,879,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2783 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1557 (estimated) No. of Female Employees: 276 (estimated)

HS Code	2904209090

98-23-7

~91%

145-39-1

HS Code	2904209090
Summary	2904209090 derivatives containing only nitro or only nitroso groups。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%