918629-48-8

918629-48-8 structure

Name: Transdermal Peptide
Chemical Name: td-1
CAS Number: 918629-48-8
Molecular Formula: C₄₀H₆₆N₁₄O₁₆S₂
Molecular Weight: 1063.17000
Catalog: Peptides
Create Date: 2018-04-20 00:28:25
Modify Date: 2024-02-01 10:20:35
Transdermal Peptide is a 11-amino acid peptide, binds to Na+/K+-ATPase beta-subunit (ATP1B1), and enhances the transdermal delivery of many macromolecules.

Name	td-1
Synonyms	Transdermal Peptide L-Alanyl-L-cysteinyl-L-seryl-L-seryl-L-seryl-L-prolyl-L-seryl-L-lysyl-L-histidyl-L-cysteinylglycine

Description	Transdermal Peptide is a 11-amino acid peptide, binds to Na+/K+-ATPase beta-subunit (ATP1B1), and enhances the transdermal delivery of many macromolecules.
Related Catalog	Signaling Pathways >> Others >> Others Peptides Research Areas >> Others
In Vitro	Transdermal Peptide (TD1) binds to ATP1B1, and mainly interacts with the C-terminus of ATP1B1 in yeast and mammalian cells. The interaction affects the expression and localization of ATP1B1 and epidermal structure, but can be antagonized by the exogenous competitor ATP1B1 or be inhibited by ouabain. Inhibition of Transdermal Peptide binding to ATP1B1 causes decreased delivery of macromolecular drugs across the skin[1].
References	[1]. Wang C, et al. Role of the Na(+)/K(+)-ATPase beta-subunit in peptide-mediated transdermal drug delivery. Mol Pharm. 2015 Apr 6;12(4):1259-67.