1281816-04-3

1281816-04-3 structure

Name: Lys-SMCC-DM1
Chemical Name: Lysine-emtansine
CAS Number: 1281816-04-3
Molecular Formula: C₅₃H₇₅ClN₆O₁₅S
Molecular Weight: 1103.71000
Catalog: Research Areas Others
Create Date: 2018-06-12 15:18:47
Modify Date: 2024-01-13 12:42:51
Lys-SMCC-DM1 is the active metabolite of T-DM1. T-DM1 is an FDA approved HER2-targeting ADC.

Name	Lysine-emtansine
Synonyms	N6-(4-((3-((3-(((S)-1-(((14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl)oxy)-1-oxopropan-2-yl)(methyl)amino)-3-oxopropyl)thio)-2,5-dioxopyrrolidin-1-yl)methyl)cyclohexane-1-carbonyl)-L-lysine

Description	Lys-SMCC-DM1 is the active metabolite of T-DM1. T-DM1 is an FDA approved HER2-targeting ADC.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
References	[1]. Ogitani Y, et al. Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity. Cancer Sci. 2016 Jul;107(7):1039-46.