1025-39-4
1025-39-4 structure
- Name: Lupanine hydrochloride
- Chemical Name: lupanine hydrochloride dihydrate
- CAS Number: 1025-39-4
- Molecular Formula: C15H25ClN2O
- Molecular Weight: 284.82500
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
- Create Date: 2018-05-04 22:17:50
- Modify Date: 2023-01-16 17:38:02
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Lupanine (D-Lupanine) hydrochloride is a natural ketonic derivative of Sparteine ((+)-Sparteine (HY-W008350)) with a ganglioplegic activity. Lupanine hydrochloride shows binding affinity for nicotinic receptor (nAChR) with a Ki value of 500 nM[1].
| Name | lupanine hydrochloride dihydrate |
|---|---|
| Synonyms |
(7S,7aS,14S,14aR)-Dodecahydro-7,14-methano-dipyrido[1,2-a
1',2'-e][1,5]diazocin-4-one hydrochloride (+)-lupanine, monohydrochloride (+)-Lupanin, Monohydrochlorid |
| Description | Lupanine (D-Lupanine) hydrochloride is a natural ketonic derivative of Sparteine ((+)-Sparteine (HY-W008350)) with a ganglioplegic activity. Lupanine hydrochloride shows binding affinity for nicotinic receptor (nAChR) with a Ki value of 500 nM[1]. |
|---|---|
| Related Catalog | |
| Target |
Ki: 500 nM (Nicotinic receptor) and 11000 nM (Muscarinic receptor)[1] |
| In Vitro | Lupanine 对烟碱受体具有结合亲和力，Ki 值为 500 nM。而 Lupanine 对毒蕈碱受体的亲和力非常弱，Ki 值为 11000 nM[1]。 Lupanine (0-100 μM) 是 SH-SY5Y 细胞的弱激动剂和脱敏剂，EC50 和 DC50 分别为 10.7 μM 和 28.2 μM[2]。 |
| In Vivo | Lupanine (腹腔注射 100-300 毫克/千克；口服 175-700 毫克/千克) 在 EOPS 雄性瑞士小鼠 (20-22 克) 和哈特利豚鼠 (400-500 克) 中单次注射的毒性要小得多[1]。 Lupanine (1-7.5 mg/kg；i.v.) 比 Sparteine 更有效地对抗颈动脉闭塞引起的继发性反射性高血压和刺激肺胃神经引起的猫狗低血压[1]。 Lupanine 对阿托品治疗的狗注射乙酰胆碱 (500 pg/kg i.v.) 引起的烟碱型高血压有抑制作用[1]。 |
| References |
| Molecular Formula | C15H25ClN2O |
|---|---|
| Molecular Weight | 284.82500 |
| Exact Mass | 284.16600 |
| PSA | 23.55000 |
| LogP | 2.54950 |