5054-59-1
5054-59-1 structure
- Name: 2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione
- Chemical Name: 2-(2,6-Dioxo-3-piperidinyl)-4-hydroxy-1H-isoindole-1,3(2H)-dione
- CAS Number: 5054-59-1
- Molecular Formula: C13H10N2O5
- Molecular Weight: 274.229
- Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
- Create Date: 2018-02-20 08:38:19
- Modify Date: 2024-01-19 16:37:02
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E3 ligase Ligand 2 is a Ligand for E3 Ligase used in PROTAC technology.
| Name | 2-(2,6-Dioxo-3-piperidinyl)-4-hydroxy-1H-isoindole-1,3(2H)-dione |
|---|---|
| Synonyms |
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-hydroxy-
2-(2,6-Dioxo-3-piperidinyl)-4-hydroxy-1H-isoindole-1,3(2H)-dione 2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione E3 ligase Ligand 2 4-Hydroxythalidomide Pomalidomide Impurity 1 |
| Description | E3 ligase Ligand 2 is a Ligand for E3 Ligase used in PROTAC technology. |
|---|---|
| Related Catalog | |
| Target |
Ligand for E3 Ligase[1] |
| In Vitro | Thalidomide may exert anti-angiogenic effect in isolated blood vessels and endothelial cells. E3 ligase Ligand 2 is a putative hydroxylated thalidomide metabolite. E3 ligase Ligand 2 has weak anti-angiogenic activity (14% mean inhibition of blood vessel density at 100 mg). E3 ligase Ligand 2 does not have any anti-proliferative effect against the breast or neuroblastoma cells, but do possess appreciable anti-proliferative activity against the endothelial cells[1]. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 568.3±45.0 °C at 760 mmHg |
| Molecular Formula | C13H10N2O5 |
| Molecular Weight | 274.229 |
| Flash Point | 297.5±28.7 °C |
| Exact Mass | 274.058960 |
| LogP | -0.20 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.679 |
| Storage condition | 2-8℃ |