521310-51-0
521310-51-0 structure
- Name: MCP110
- Chemical Name: N-[4-(Benzyloxy)-3-methoxybenzyl]-5-phenyl-N-[2-(2-pyridinyl)ethyl]pentanamide
- CAS Number: 521310-51-0
- Molecular Formula: C33H36N2O3
- Molecular Weight: 508.651
- Catalog: Signaling Pathways GPCR/G Protein Ras
- Create Date: 2018-04-24 09:17:15
- Modify Date: 2024-01-30 00:37:11
-
MCP110 is an inhibitor of Ras/Raf-1 interaction. MCP110 blocks the interaction of Ras with Raf[1].
| Name | N-[4-(Benzyloxy)-3-methoxybenzyl]-5-phenyl-N-[2-(2-pyridinyl)ethyl]pentanamide |
|---|---|
| Synonyms |
Benzenepentanamide, N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-N-[2-(2-pyridinyl)ethyl]-
N-[4-(benzyloxy)-3-methoxybenzyl]-5-phenyl-N-[2-(pyridin-2-yl)ethyl]pentanamide N-[4-(Benzyloxy)-3-methoxybenzyl]-5-phenyl-N-[2-(2-pyridinyl)ethyl]pentanamide N-(4-(benzyloxy)-3-methoxybenzyl)-5-phenyl-N-(2-(pyridin-2-yl)ethyl)pentanamide MCP110 |
| Description | MCP110 is an inhibitor of Ras/Raf-1 interaction. MCP110 blocks the interaction of Ras with Raf[1]. |
|---|---|
| Related Catalog | |
| Target |
Ras RAF |
| In Vitro | MCP110 (10 and 20 uM) inhibits H-Ras (V12)-induced AP-1 activation in HEK293 cells. Ras stimulation of Raf-1 activity is significantly decreased by MCP110 (20 μM) [1]. MCP110 (1, 2, 5, 10, and 20 μM) shows a dose-dependent inhibition of elevated Raf-1 activity in fibrosarcoma HT1080 cells[1]. MCP110 (20 μM) decreases cyclin D level stimulated by the treatment with EGF (100 ng/mL), platelet-derived growth factor (20 ng/mL) , serum, or phorbol 12-myristate 13-acetate (100 nM) in A549 cells[1]. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 686.3±55.0 °C at 760 mmHg |
| Molecular Formula | C33H36N2O3 |
| Molecular Weight | 508.651 |
| Flash Point | 368.8±31.5 °C |
| Exact Mass | 508.272583 |
| LogP | 6.24 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.594 |