1219804-79-1

1219804-79-1 structure

Name: 4-Methylcatechol-d6
Chemical Name: 4-(2H3)Methyl(2H3)-1H-imidazole
CAS Number: 1219804-79-1
Molecular Formula: C₄D₆N₂
Molecular Weight: 88.141
Catalog: Research Areas Others
Create Date: 2018-06-11 00:11:28
Modify Date: 2024-04-06 12:05:46
4-Methylcatechol-d6 is the deuterium labeled 4-Methylcatechol[1]. 4-Methylcatechol, a metabolite of p-toluate, is a substrate as well as a suicide inhibitor of Catechol 2,3-Dioxygenase[2].

Name	4-(2H3)Methyl(2H3)-1H-imidazole
Synonyms	1H-Imidazole-1,2,5-d, 4-(methyl-d)- 4-(H)Methyl(H)-1H-imidazole

Description	4-Methylcatechol-d6 is the deuterium labeled 4-Methylcatechol[1]. 4-Methylcatechol, a metabolite of p-toluate, is a substrate as well as a suicide inhibitor of Catechol 2,3-Dioxygenase[2].
Related Catalog	Research Areas >> Others
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Okuta A, et al. Construction of chimeric catechol 2,3-dioxygenase exhibiting improved activity against the suicide inhibitor 4-methylcatechol. Appl Environ Microbiol. 2004 Mar;70(3):1804-10.