80221-58-5

80221-58-5 structure

Name: Pipequaline hydrochloride
Chemical Name: 2-phenyl-4-(2-piperidin-4-ylethyl)quinoline,hydrochloride
CAS Number: 80221-58-5
Molecular Formula: C₂₂H₂₅ClN₂
Molecular Weight: 352.90
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2017-03-26 11:47:02
Modify Date: 2025-08-27 07:12:55
Pipequaline hydrochloride (PK-8165 hydrochloride) is a partial benzodiazepine receptor agonist with anxiolytic activity[1][2].

Name	2-phenyl-4-(2-piperidin-4-ylethyl)quinoline,hydrochloride
Synonyms	2-phenyl-4-(2-piperidin-4-ylethyl)quinoline hydrochloride 2-Phenyl-4-(2-(4-piperidyl)ethyl)quinoline monohydrochloride Quinoline,2-phenyl-4-(2-(4-piperidinyl)ethyl)-,monohydrochloride 2-Phenyl-4-(2-(4-piperidinyl)ethyl)quinoline monohydrochloride

Description	Pipequaline hydrochloride (PK-8165 hydrochloride) is a partial benzodiazepine receptor agonist with anxiolytic activity[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Target	Benzodiazepine receptor[1]
References	[1]. Bradwejn J, et al. Effects of PK 8165, a partial benzodiazepine receptor agonist, on cholecystokinin-inducedactivation of hippocampal pyramidal neurons: a microiontophoretic study in the rat. Eur J Pharmacol. 1985 Jun 19;112(3):415-8. [2]. Debonnel G, et al. Pipequaline acts as a partial agonist of benzodiazepine receptors: an electrophysiological study in the hippocampus of the rat. Neuropharmacology. 1987 Sep;26(9):1337-42.