108708-22-1

108708-22-1 structure

Name: 6-NBDG
Chemical Name: D-Glucose, 6-deoxy-6-((7-nitro-4-benzofurazanyl)amino)-
CAS Number: 108708-22-1
Molecular Formula: C₁₂H₁₄N₄O₈
Molecular Weight: 342.262
Catalog: Research Areas Others
Create Date: 2018-04-05 12:37:22
Modify Date: 2025-08-24 17:43:37
6-NBDG is a fluorescent glucose analogue, it can be used for fluorescence imaging and monitoring glucose transport and uptake. 6-NBDG can be used as a fluorescent probe for detecting macrophage-rich atherosclerotic plaques[1][2].

Name	D-Glucose, 6-deoxy-6-((7-nitro-4-benzofurazanyl)amino)-
Synonyms	6-Deoxy-6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose D-Glucose, 6-deoxy-6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]- D-Glucose, 6-deoxy-6-((7-nitro-4-benzofurazanyl)amino)-

Description	6-NBDG is a fluorescent glucose analogue, it can be used for fluorescence imaging and monitoring glucose transport and uptake. 6-NBDG can be used as a fluorescent probe for detecting macrophage-rich atherosclerotic plaques[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs). 1. Incubate sample with RPMI (without glucose) containing a final concentration of 200 μM 6-NBDG. 2. Use a curved forcep to embeds sample into the mixture, and stretches the samplet through a drop of agarose (40°C, 20 μL) places on a pre-heated (40°C) glass slide. 3. Gently place another preheated glass slide on the top of sample, so that the whole sample embeds into the agarose-6-NBDG mixture. 4. Take confocal images with a confocal laser scanning microscope (Ex: 471 nm, Em: 500–600 nm)[2].
References	[1]. Hansen TV, et al. Glucose Absorption by the Bacillary Band of Trichuris muris. PLoS Negl Trop Dis. 2016 Sep 2;10(9):e0004971. [2]. Zaman RT, et al. Fiber-optic system for dual-modality imaging of glucose probes 18F-FDG and 6-NBDG in atherosclerotic plaques. PLoS One. 2014 Sep 18;9(9):e108108.