202801-92-1
202801-92-1 structure
- Name: Orexin B (mouse, rat)
- Chemical Name: Orexin B
- CAS Number: 202801-92-1
- Molecular Formula: C126H215N45O34S
- Molecular Weight: 2936.401
- Catalog: Biochemical Peptide
- Create Date: 2018-07-03 09:28:21
- Modify Date: 2026-07-17 08:27:24
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Orexin B, rat, mouse is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.
| Name | Orexin B |
|---|---|
| Synonyms |
OREXIN B (RAT, MOUSE)
OREXIN B (MOUSE) G-PRO-GLY-PRO-PRO-GLY-LEU-GLN-GLY-G-LEU-GLN-G-LEU-LEU-GLN-ALA-ASN-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2 HYPOCRETIN-B, MOUSE Hypocretin-2 (Mouse, rat) OREXINS OREXIN B RAT, MOUSE L-Arginyl-L-prolylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-asparaginylglycyl-L-asparaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucyl-L-leucyl-L-threonyl-L-methioninamide Rat orexin B REF DUPL: H-g-Pro-Gly-Pro-Pro-Gly-Leu-Gln-Gly-g-Leu-Gln-g-Leu-Leu-Gln-Ala-Asn-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2 Orexin B, mouse/rat OREXIN B (MOUSE, RAT) Orexin B (Mouse, rat) Hypocretin-2 (Mouse, rat) RPGPPGLQLQRLLQANGNHAAGILTM-NH2 Orexin B (rat, mouse), (HPLC) G-PRO-GLY-PRO-PRO-GLY-LEU-GLN-GLY-G-LEU-GLN-G- LEU-LEU-GLN-ALA-ASN-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2 H-G-PRO-GLY-PRO-PRO-GLY-LEU-GLN-GLY-G-LEU-GLN-G-LEU-LEU-GLN-ALA-ASN-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2 OREXIN-B (RAT, HUMAN) Orexin B, rat, mouse L-Methioninamide, L-ginyl-L-prolylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-ginyl-L-leucyl-L-glutaminyl-L-ginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-aspaginylglycyl-L-aspaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucyl-L-leucyl-L-threonyl- (9CI) H-G-PRO-GLY-PRO-PRO-GLY-LEU-GLN-GLY-G-LEU-GLN-G-LEU-LEU-GLN-ALA-ASN-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2 //BP |
| Description | Orexin B, rat, mouse is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively. |
|---|---|
| Related Catalog | |
| Target |
Ki: 420 nM (OX1), 36 nM (OX2)[1] |
| In Vitro | Orexin B is derived by proteolytic amino acid precursor, prepro-orexin, which is encoded by a gene localized to chromosome 17q21 in humans. In radioligand binding studies, Orexin B has a higher affinity for the OX2 receptor[1]. Human Orexin B has two amino acid substitutions when compared with the rodent sequence. OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC50 of 36 nM in the binding assay and an EC50 of 60 nM in the [Ca2+]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC50 in the competitive binding assay and the EC50 in the [Ca2+]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively[2]. |
| In Vivo | Human Orexin B significantly augments food intake; at the 2 hr time point, 5- and 12-fold stimulation of food consumption is observed by 3 nM and 30 nM orexin-B, respectively[2]. |
| Animal Admin | Rats[2] 3 nM and 30 nM of synthetic human Orexin B is administered in a 5 mL bolus through a catheter placed in the left lateral ventricle of Male Wistar rats (180–200 g) in early light phase. Cumulative food consumption is observed and plotted over the period of 4 hr after injection[2]. |
| References |
[1]. Smart D, et al. Orexins: a new family of neuropeptides. Br J Anaesth. 1999 Nov;83(5):695-7. |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C126H215N45O34S |
| Molecular Weight | 2936.401 |
| Exact Mass | 2934.619873 |
| LogP | -9.21 |
| Index of Refraction | 1.670 |
| Storage condition | −20°C |
| Water Solubility | Soluble in 1% acetic acid at 1mg/ml |
| WGK Germany | 3 |
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