1884226-20-3

1884226-20-3 structure

Name: REDX-05358
Chemical Name: REDX05358
CAS Number: 1884226-20-3
Molecular Formula: C₂₆H₂₁ClN₄O₃
Molecular Weight: 472.9
Catalog: Signaling Pathways MAPK/ERK Pathway Raf
Create Date: 2018-04-29 11:56:57
Modify Date: 2026-07-15 14:28:29
Anticancer agent 124 is an orally active, highly selective and potent pan RAF inhibitor. Anticancer agent 124 inhibits MAPK signalling in BRAF V600E, NRAS and KRAS mutant tumor cells[1].

Name	REDX05358
Synonyms	1,8-Naphthyridin-2(1H)-one, 5-[[3-[5-(2-chlorophenyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-1-benzopyran-6-yl]oxy]-3,4-dihydro

Description	Anticancer agent 124 is an orally active, highly selective and potent pan RAF inhibitor. Anticancer agent 124 inhibits MAPK signalling in BRAF V600E, NRAS and KRAS mutant tumor cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> Raf
References	[1]. Helen Mason, et al. Abstract 5160: Development of REDX05358, a novel highly selective and potent pan RAF inhibitor and a potential therapeutic for BRAF and RAS mutant tumors. Cancer Res 1 July 2017; 77 (13_Supplement): 5160.