1334237-71-6

1334237-71-6 structure

Name: AMG-416
Chemical Name: etelcalcetide hydrochloride
CAS Number: 1334237-71-6
Molecular Formula: C₃₈H₇₃N₂₁O₁₀S_2.xClH
Molecular Weight: 1084.712
Catalog: Signaling Pathways GPCR/G Protein CaSR
Create Date: 2018-01-07 18:18:50
Modify Date: 2025-08-25 15:11:40
Etelcalcetide hydrochloride (AMG 416 hydrochloride) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide hydrochloride is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis[1].

Name	etelcalcetide hydrochloride
Synonyms	(6R,9R,12R,15R,18R,21R,24S,29R)-24-Acetamido-1,29-diamino-12,15,18-tris(3-carbamimidamidopropyl)-6-carbamoyl-1-imino-9,21-dimethyl-8,11,14,17,20,23-hexaoxo-26,27-dithia-2,7,10,13,16,19,22-heptaazatriacontan-30-oic acid hydrochloride (1:1) AMG 416 velcalcetide hydrochloride etelcalcetide hydrochloride KAI-4169 UNII:72PT5993DU AMG-416

Description	Etelcalcetide hydrochloride (AMG 416 hydrochloride) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide hydrochloride is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis[1].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> CaSR
References	[1]. Block GA, et al. Effect of Etelcalcetide vs Cinacalcet on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: A Randomized Clinical Trial. JAMA. 2017 Jan 10;317(2):156-164.