1796565-52-0

1796565-52-0 structure

Name: Orexin 2 Receptor Agonist
Chemical Name: 4'-Methoxy-N,N-dimethyl-3'-{[3-({2-[(3-methylbenzoyl)amino]ethyl}amino)phenyl]sulfamoyl}-3-biphenylcarboxamide
CAS Number: 1796565-52-0
Molecular Formula: C₃₂H₃₄N₄O₅S
Molecular Weight: 586.701
Catalog: Signaling Pathways GPCR/G Protein Orexin Receptor (OX Receptor)
Create Date: 2018-11-28 15:44:15
Modify Date: 2024-01-22 05:54:42
Orexin 2 Receptor Agonist is a potent (EC50 on OX2R is 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio is 70) agonist.IC50 value: 23 nM (EC50)Target: Orexin 2 ReceptorOrexin 2 Receptor Agonist shows not only potentactivity but also high selectivity for OX2R over OX1R. In CHO cells overexpressing hOX1R and HEK-293 cells overexpressing hOX2R, compound 26 displaced [125I]orexin-A in a concentration dependent manner: 26 bound to hOX2R and hOX1R with Ki of 0.14 and 0.77 μM, respectively.[1]

Name	4'-Methoxy-N,N-dimethyl-3'-{[3-({2-[(3-methylbenzoyl)amino]ethyl}amino)phenyl]sulfamoyl}-3-biphenylcarboxamide
Synonyms	Benzamide, N-[2-[[3-[[[3'-[(dimethylamino)carbonyl]-4-methoxy[1,1'-biphenyl]-3-yl]sulfonyl]amino]phenyl]amino]ethyl]-3-methyl- 4'-Methoxy-N,N-dimethyl-3'-{[3-({2-[(3-methylbenzoyl)amino]ethyl}amino)phenyl]sulfamoyl}-3-biphenylcarboxamide Orexin 2 Receptor Agonist MDK-5220

Description	Orexin 2 Receptor Agonist is a potent (EC50 on OX2R is 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio is 70) agonist.IC50 value: 23 nM (EC50)Target: Orexin 2 ReceptorOrexin 2 Receptor Agonist shows not only potentactivity but also high selectivity for OX2R over OX1R. In CHO cells overexpressing hOX1R and HEK-293 cells overexpressing hOX2R, compound 26 displaced [125I]orexin-A in a concentration dependent manner: 26 bound to hOX2R and hOX1R with Ki of 0.14 and 0.77 μM, respectively.[1]
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Orexin Receptor (OX Receptor) Research Areas >> Neurological Disease
References	[1]. Nagahara T, et al. Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists. J Med Chem. 2015 Oct 22;58(20):7931-7.