2012607-27-9

2012607-27-9 structure

Name: WNK463
Chemical Name: N-(2-Methyl-2-propanyl)-1-(1-{5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]-2-pyridinyl}-4-piperidinyl)-1H-imidazole-5-carboxamide
CAS Number: 2012607-27-9
Molecular Formula: C₂₁H₂₄F₃N₇O₂
Molecular Weight: 463.456
Catalog: Research Areas Cancer
Create Date: 2018-03-04 20:15:17
Modify Date: 2025-08-26 20:38:50
WNK463 is an orally bioavailable pan-WNK-kinase inhibitor with IC50s of 5, 1, 6, and 9 nM for WNK1, WNK 2, WNK 3, and WNK 4, respectively.

Name	N-(2-Methyl-2-propanyl)-1-(1-{5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]-2-pyridinyl}-4-piperidinyl)-1H-imidazole-5-carboxamide
Synonyms	N-(2-Methyl-2-propanyl)-1-(1-{5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]-2-pyridinyl}-4-piperidinyl)-1H-imidazole-5-carboxamide 1H-Imidazole-5-carboxamide, N-(1,1-dimethylethyl)-1-[1-[5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]-2-pyridinyl]-4-piperidinyl]- WNK463

Description	WNK463 is an orally bioavailable pan-WNK-kinase inhibitor with IC50s of 5, 1, 6, and 9 nM for WNK1, WNK 2, WNK 3, and WNK 4, respectively.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
References	[1]. Yamada K et al. Small-molecule WNK inhibition regulates cardiovascular and renal function. Nat Chem Biol. 2016 Nov;12(11):896-898.