Shanghai Nianxing Industrial Co., Ltd
China
Product Name: NSC23005(sodium)
Price:
Purity: 99.0%
Stocking Period: 10 Day
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: NSC23005 sodium
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

DC Chemicals Limited
China
Product Name: NSC23005 sodium
Price: $350.0/100mg $600.0/250mg $1200.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: NSC23005 Sodium
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Contact: Ms Wang

1796596-46-7

1796596-46-7 structure

1796596-46-7 structure

Name: NSC 23005 sodium
Chemical Name: NSC23005 sodium
CAS Number: 1796596-46-7
Molecular Formula: C₁₃H₁₆NNaO₄S
Molecular Weight: 305.324
Catalog: Research Areas Cancer
Create Date: 2018-06-30 09:57:51
Modify Date: 2024-01-08 18:37:15
NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.

Name	NSC23005 sodium
Synonyms	NSC23005 (sodium)

Description	NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
Target	ED50: 5.21 nM (p18INK4C)[1]
In Vitro	NSC23005 sodium is a novel class of INK4C (p18INK4C or p18) small molecule inhibitor (p18SMIs), which is initially found by in silico 3D screening. NSC23005 sodium shows the most potent bioactivity in hematopoietic stem cells (HSCs) expansion (ED50=5.21 nM). Notably, NSC23005 sodium does not show significant cytotoxicity toward 32D cells or HSCs, nor does it augment leukemia cell proliferation. NSC23005 sodium (ED50=5.21 nM), shows no activity in promoting the proliferation of leukemia cells[1].
In Vivo	NSC23005 sodium selectively promote HSCs division by inhibiting p18, thereby activating CDK4/6. NSC23005 sodium is a novel and effective p18 inhibitor in promoting HSCs expansion in both murine and human models[1].
Cell Assay	c-Kit enriched bone marrow (BM) cells are cultured for 5 days with cytokine combination plus NSC23005 sodium or DMSO. As positive controls, primary uncultured bone marrow cells are treated by ultraviolet radiation (UV) for 10 minutes prior to the staining process for apoptosis analysis. Apoptosis and cell death are measured by AnnexinV and DAPI staining in the Annexin V-FITC Apoptosis Detection Kit. Apoptosis is measured on an FACS analyzer. The data is analyzed using FlowJo software[1].
References	[1]. Xie XQ, et al. Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion. Sci Rep. 2015 Dec 18;5:18115.

Molecular Formula	C₁₃H₁₆NNaO₄S
Molecular Weight	305.324
Exact Mass	305.07
Storage condition	2-8℃