Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: DISODIUM FOLINATE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

163254-40-8

163254-40-8 structure

Name: DISODIUM FOLINATE
Chemical Name: UNII:4MXU9LJS4Q
CAS Number: 163254-40-8
Molecular Formula: C₂₀H₂₁N₇Na₂O₇
Molecular Weight: 517.403
Catalog: Biochemical Amino acids and their derivatives Glutamic acid derivative
Create Date: 2018-08-01 19:16:39
Modify Date: 2024-01-10 22:35:01
Folinic acid (Leucovorin) disodium is a biological folic acid and is a forms of vitamin B9. Folinic acid disodium is generally administered along with Methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity. Folinic acid disodium and Sfluorouracil adjuvant chemotherapy shows effective in colon carcinoma[1][2][3].

Name	UNII:4MXU9LJS4Q
Synonyms	UNII:4MXU9LJS4Q L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, sodium salt (1:2) Disodium (2S)-2-[(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydro-6-pteridinyl)methyl]amino}benzoyl)amino]pentanedioate MFCD11618008

Description	Folinic acid (Leucovorin) disodium is a biological folic acid and is a forms of vitamin B9. Folinic acid disodium is generally administered along with Methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity. Folinic acid disodium and Sfluorouracil adjuvant chemotherapy shows effective in colon carcinoma[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Antifolate
Target	Human Endogenous Metabolite
In Vitro	Folinic acid disodium (5, 50 µg/ml; 40 h) significantly reduces % micronucleated binucleated cells (MNBN) (40%-68%) and % aberrant cells (Abs) (36%-77%) in V79 cells that were treated with MTX at five different concentrations 5–100 mg/ml for 6 h[1].
In Vivo	Folinic acid disodium (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following Methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)[2]. Animal Model: 24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)[2] Dosage: 7.0 mg/kg Administration: Intraperitoneal injection; every second day; for 3 weeks Result: Following MTX administration appears to reverse this growth inhibition.
References	[1]. Keshava, C., et al., Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res, 1998. 397(2): p. 221-8. [2]. Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44. [3]. Francini G, et al. Folinic acid and 5-fluorouracil as adjuvant chemotherapy in colon cancer. Gastroenterology. 1994 Apr;106(4):899-906.

Molecular Formula	C₂₀H₂₁N₇Na₂O₇
Molecular Weight	517.403
Exact Mass	517.129761

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