163254-40-8
163254-40-8 structure
- Name: DISODIUM FOLINATE
- Chemical Name: UNII:4MXU9LJS4Q
- CAS Number: 163254-40-8
- Molecular Formula: C20H21N7Na2O7
- Molecular Weight: 517.403
- Catalog: Biochemical Amino acids and their derivatives Glutamic acid derivative
- Create Date: 2018-08-01 19:16:39
- Modify Date: 2024-01-10 22:35:01
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Folinic acid (Leucovorin) disodium is a biological folic acid and is a forms of vitamin B9. Folinic acid disodium is generally administered along with Methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity. Folinic acid disodium and Sfluorouracil adjuvant chemotherapy shows effective in colon carcinoma[1][2][3].
| Name | UNII:4MXU9LJS4Q |
|---|---|
| Synonyms |
UNII:4MXU9LJS4Q
L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, sodium salt (1:2) Disodium (2S)-2-[(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydro-6-pteridinyl)methyl]amino}benzoyl)amino]pentanedioate MFCD11618008 |
| Description | Folinic acid (Leucovorin) disodium is a biological folic acid and is a forms of vitamin B9. Folinic acid disodium is generally administered along with Methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity. Folinic acid disodium and Sfluorouracil adjuvant chemotherapy shows effective in colon carcinoma[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | Folinic acid disodium (5, 50 µg/ml; 40 h) significantly reduces % micronucleated binucleated cells (MNBN) (40%-68%) and % aberrant cells (Abs) (36%-77%) in V79 cells that were treated with MTX at five different concentrations 5–100 mg/ml for 6 h[1]. |
| In Vivo | Folinic acid disodium (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following Methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)[2]. Animal Model: 24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)[2] Dosage: 7.0 mg/kg Administration: Intraperitoneal injection; every second day; for 3 weeks Result: Following MTX administration appears to reverse this growth inhibition. |
| References |
| Molecular Formula | C20H21N7Na2O7 |
|---|---|
| Molecular Weight | 517.403 |
| Exact Mass | 517.129761 |