2016795-77-8
2016795-77-8 structure
- Name: EC330
- Chemical Name: EC330
- CAS Number: 2016795-77-8
- Molecular Formula: C30H32F2O2
- Molecular Weight: 462.57
- Catalog: Research Areas Cancer
- Create Date: 2018-03-26 15:21:58
- Modify Date: 2025-08-25 07:30:38
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EC330 is a leukemia inhibitory factor (LIF) inhibitor.
| Name | EC330 |
|---|
| Description | EC330 is a leukemia inhibitory factor (LIF) inhibitor. |
|---|---|
| Related Catalog | |
| In Vitro | EC330 shows marked specificity in MCF-7 cells overexpressing LIF verses MCF-7 cells. EC330 further shows cytoskeletal disruption and targeting cancer-associated fibroblasts (CAFs) through inhibition of alpha-SMA but not beta-tubulin[1]. |
| In Vivo | EC330 treatment (0.1, 0.5 and 2.5 mg/kg) dose dependently reduces tumor burden in ovarian (IGROV-1) and triple negative breast cancer (MDA-MB-231) cell xenografted mouse models as well as MDA-MB-231 PDX models. EC330 exhibits no reactivity towards thiol-cysteine residues, no off target binding to major receptors, kinases or ion channels. EC330 is orally bioavailable and found to be safe and tolerable in toxicity studies[1]. |
| References |
| Molecular Formula | C30H32F2O2 |
|---|---|
| Molecular Weight | 462.57 |
| Storage condition | 2-8℃ |
| Water Solubility | 10 mM in DMSO |