174422-72-1

174422-72-1 structure

Name: Mal-C2-cyclohexylcarboxyl-hydrazide hydrochloride
Chemical Name: 4-[N-MALEIMIDOMETHYL]CYCLOHEXANE-1-CARBOXYLHYDRAZIDE HCL 1/2 DIOXANE
CAS Number: 174422-72-1
Molecular Formula: C₁₂H₁₈ClN₃O₃
Molecular Weight: 287.74
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-05-29 23:00:42
Modify Date: 2024-01-10 18:38:24
Mal-C2-cyclohexylcarboxyl-hydrazide hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	4-[N-MALEIMIDOMETHYL]CYCLOHEXANE-1-CARBOXYLHYDRAZIDE HCL 1/2 DIOXANE

Description	Mal-C2-cyclohexylcarboxyl-hydrazide hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl-Chain
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula	C₁₂H₁₈ClN₃O₃
Molecular Weight	287.74