DC Chemicals Limited
China
Product Name: PF-06459988
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

1428774-45-1

1428774-45-1 structure

1428774-45-1 structure

Name: PF-06459988
Chemical Name: PF-06459988
CAS Number: 1428774-45-1
Molecular Formula:
Molecular Weight:
Catalog: Research Areas Cancer
Create Date: 2018-05-16 06:16:01
Modify Date: 2024-01-19 10:39:39
PF-06459988 is an irreversible inhibitor of T790M-Containing EGFR Mutants.

Name	PF-06459988
Synonyms	1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one

Description	PF-06459988 is an irreversible inhibitor of T790M-Containing EGFR Mutants.
Related Catalog	Research Areas >> Cancer
Target	IC50: 45 nM (H1975 EGFR), 3.3 μM (EGFR)
References	[1]. Cheng H, et al. Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants. J Med Chem. 2016 Mar 10;59(5):2005-24. doi: 10.1021/acs.jmedchem.5b01633. Epub 2016 Jan 28.

Storage condition	2-8℃

RIDADR	NONH for all modes of transport