- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Vaborbactam
- Price:
- Purity: 99.0%
- Stocking Period: 10 Day
- Contact: Huang
- DC Chemicals Limited
- China
- Product Name: Vaborbactam
- Price: $950.0/100mg $1900.0/250mg $3800.0/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Vaborbactam
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
1360457-46-0
1360457-46-0 structure
- Name: Vaborbactam
- Chemical Name: vaborbactam
- CAS Number: 1360457-46-0
- Molecular Formula: C12H16BNO5S
- Molecular Weight: 297.135
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2018-05-20 08:00:00
- Modify Date: 2024-01-02 20:18:06
-
Vaborbactam is a cyclic boronic acid pharmacophore β-lactamase inhibitor.
| Name | vaborbactam |
|---|---|
| Synonyms |
1,2-Oxaborinane-6-acetic acid, 2-hydroxy-3-[[2-(2-thienyl)acetyl]amino]-, (3R,6S)-
{(3R,6S)-2-Hydroxy-3-[(2-thienylacetyl)amino]-1,2-oxaborinan-6-yl}acetic acid RPX7009 UNII:1C75676F8V vaborbactam |
| Description | Vaborbactam is a cyclic boronic acid pharmacophore β-lactamase inhibitor. |
|---|---|
| Related Catalog | |
| In Vitro | Vaborbactam is a broad spectrum of inhibition of β-lactamases, with particularly potent activity against KPC, CTX-M, SHV, and CMY enzymes[1]. Vaborbactam restores meropenem activity for 72.7 to 98.1% of CPE isolates at ≤2 μg/mL, and maximum potentiation is achieved with fixed concentrations of ≥8 μg/mL of the inhibitor (≥96.5% of isolates are inhibited at ≤2 μg/mL of meropenem-vaborbactam). Meropenem-vaborbactam with a fixed concentration of 8 μg/mL of the inhibitor (MIC50, ≤0.06 μg/mL for all organisms) inhibits 93.7% of the CPE isolates displaying elevated meropenem MICs at ≤1 μg/mL[2]. By forming a reversible dative bond with the blactamase, vaborbactam acts as a competitive inhibitor and is not hydrolyzed by the b-lactamase[3]. |
| In Vivo | Vaborbactam is well tolerated and has a half-life of 1.23 h, and steadystate volume of distribution of 21.0 L in subjects[3]. |
| References |
[3]. Wong D, et al. Novel Beta-Lactamase Inhibitors: Unlocking Their Potential in Therapy. |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C12H16BNO5S |
| Molecular Weight | 297.135 |
| Exact Mass | 297.084229 |
| Index of Refraction | 1.572 |
| Storage condition | 2-8℃ |