579515-63-2

579515-63-2 structure

Name: GW806742X
Chemical Name: GW806742X
CAS Number: 579515-63-2
Molecular Formula: C₂₅H₂₂F₃N₇O₄S
Molecular Weight: 573.55
Catalog: Signaling Pathways MAPK/ERK Pathway Mixed Lineage Kinase
Create Date: 2018-02-09 08:52:49
Modify Date: 2024-01-09 22:09:25
GW806742X is a Mixed Lineage Kinase Domain-Like (MLKL) inhibitor which binds the MLKL pseudokinase domain with a Kd value of 9.3 μM and anti-necroptosis activity. GW806742X has activity against VEGFR2[1][2].

Name	GW806742X
Synonyms	MFCD29036385 3-[(4-{Methyl[4-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)phenyl]amino}-2-pyrimidinyl)amino]benzenesulfonamide 3-[(4-{methyl[4-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)phenyl]amino}pyrimidin-2-yl)amino]benzenesulfonamide Benzenesulfonamide, 3-[[4-[methyl[4-[[[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]phenyl]amino]-2-pyrimidinyl]amino]-

Description	GW806742X is a Mixed Lineage Kinase Domain-Like (MLKL) inhibitor which binds the MLKL pseudokinase domain with a Kd value of 9.3 μM and anti-necroptosis activity. GW806742X has activity against VEGFR2[1][2].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> Mixed Lineage Kinase Research Areas >> Others Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	Kd: 9.3 μM (MLKL)[1]
References	[1]. Hildebrand JM, et al. Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15072-7. [2]. Yan B, et al. Discovery of a new class of highly potent necroptosis inhibitors targeting the mixed lineagekinase domain-like protein. Chem Commun (Camb). 2017 Mar 28;53(26):3637-3640.