DC Chemicals Limited
China
Product Name: CGP4540(Amoscanate)
Price: $750.0/100mg $1300.0/250mg $2700.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

100990-46-3

100990-46-3 structure

Name: CGP4540(Amoscanate)
Chemical Name: CGP4540
CAS Number: 100990-46-3
Molecular Formula: C₁₃H₉N₃O₂S
Molecular Weight: 271.29
Catalog: Research Areas Others
Create Date: 2018-06-08 16:00:51
Modify Date: 2024-01-09 12:44:35
Amoscanate (cgp4540) is phenyl isothiocyanate in which the hydrogen at the para-position has been replaced by a 4-nitroanilinyl group. Amoscanate is an anti-schistosomal agent. Amoscanate, as an isothiocyanate compound and uncoupler of oxidative phosphorylation, potently injures rodent ependyma[1].

Name	CGP4540

Description	Amoscanate (cgp4540) is phenyl isothiocyanate in which the hydrogen at the para-position has been replaced by a 4-nitroanilinyl group. Amoscanate is an anti-schistosomal agent. Amoscanate, as an isothiocyanate compound and uncoupler of oxidative phosphorylation, potently injures rodent ependyma[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vivo	Amoscanate (500 mg/kg; p.o.; 10 days) destructs ependyma and periventricular brain[1]. Amoscanate (250 and 500 mg/kg; p.o.; 28 days) elicits necrosis, Ca++-positive microgranules, pyknosis and edema localized in ependyma/subependyma in the medial striatum[1]. Amoscanate (25~500 mg/kg; p.o.; 20 days) elicits progressive necrosis of ependyma[1]. Amoscanate elicits massive ultrastructural damage in ependymal cells[1]. Animal Model: Sprague-Dawley rats[1] Dosage: 500 mg/kg Administration: P.o.; 10 days Result: Destructed ependyma and periventricular brain. Animal Model: Sprague-Dawley rats[1] Dosage: 250 and 500 mg/kg Administration: P.o.; 28 days Result: Elicited necrosis, Ca++-positive microgranules, pyknosis and edema localized in ependyma/subependyma in the medial striatum. Animal Model: Sprague-Dawley rats[1] Dosage: 25~500 mg/kg Administration: P.o.; 20 days Result: Elicited progressive necrosis of ependymal.
References	[1]. Johanson C, et al. The distributional nexus of choroid plexus to cerebrospinal fluid, ependyma and brain: toxicologic/pathologic phenomena, periventricular destabilization, and lesion spread. Toxicol Pathol. 2011;39(1):186-212.

Molecular Formula	C₁₃H₉N₃O₂S
Molecular Weight	271.29
Storage condition	2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO