1198786-98-9

1198786-98-9 structure

Name: INT-777 R-enantiomer
Chemical Name: INT-777 R-enantiomer
CAS Number: 1198786-98-9
Molecular Formula: C₂₇H₄₆O₅
Molecular Weight: 450.651
Catalog: Signaling Pathways GPCR/G Protein GPCR19
Create Date: 2018-01-22 10:20:58
Modify Date: 2024-01-14 23:04:06
INT-777 (R-enantiomer) is the R-enantiomer of INT-777, with EC50 of 4.79 μM for TGR5, and less potent than INT-777.

Name	INT-777 R-enantiomer
Synonyms	(2R,4R)-4-[(3R,5S,6R,7R,8R,9S,10S,12S,13R,14S,17R)-6-Ethyl-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid INT-777 (R-enantiomer)

Description	INT-777 (R-enantiomer) is the R-enantiomer of INT-777, with EC50 of 4.79 μM for TGR5, and less potent than INT-777.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GPCR19 Research Areas >> Others
In Vivo	INT-777 (R-enantiomer) is more choleretic than CA (4), but less than INT-777[1].
References	[1]. Pellicciari R, et al. Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. J Med Chem. 2009 Dec 24;52(24):7958-61.