1282041-94-4

1282041-94-4 structure

Name: DSM265
Chemical Name: DSM265
CAS Number: 1282041-94-4
Molecular Formula: C₁₄H₁₂F₇N₅S
Molecular Weight: 415.332
Catalog: Signaling Pathways Anti-infection Parasite
Create Date: 2018-05-20 18:24:07
Modify Date: 2024-01-10 19:32:44
DSM265 is a PfDHODH inhibitor with an IC50 of 8.9 nM. DSM265 can also inhibit the growth of P. falciparum 3D7 parasites with an EC50 of 4.3 nM.

Name	DSM265
Synonyms	Sulfur, [4-[[2-(1,1-difluoroethyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]amino]phenyl]pentafluoro- 2-(1,1-Difluoroethyl)-5-methyl-N-[4-(pentafluoro-λ6-sulfanyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine

Description	DSM265 is a PfDHODH inhibitor with an IC50 of 8.9 nM. DSM265 can also inhibit the growth of P. falciparum 3D7 parasites with an EC50 of 4.3 nM.
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection
Target	IC50: 8.9 nM (PfDHODH)[1] EC50: 4.3 nM (P. falciparum 3D7 parasites)[1]
References	[1]. Kokkonda S, et al. Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparumDihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity. J Med Chem. 2016 Jun 9;59(11):5416-31.