1351927-00-8

1351927-00-8 structure

Name: T338C Src-IN-2
Chemical Name: T338C Src-IN-2
CAS Number: 1351927-00-8
Molecular Formula: C₁₇H₁₈FN₅O
Molecular Weight: 327.356
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Src
Create Date: 2018-06-24 23:42:55
Modify Date: 2024-01-12 11:43:38
T338C Src-IN-2 is a potent mutant c-Src T338C kinase inhibitor with IC50 of 317 nM; also inhibits T338C/V323A and T338C/V323S with IC50 of 57 nM/19 nM.

Name	T338C Src-IN-2
Synonyms	1-{3-[(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)methyl]phenyl}-2-fluoroethanone Ethanone, 1-[3-[[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]methyl]phenyl]-2-fluoro-

Description	T338C Src-IN-2 is a potent mutant c-Src T338C kinase inhibitor with IC50 of 317 nM; also inhibits T338C/V323A and T338C/V323S with IC50 of 57 nM/19 nM.
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src Research Areas >> Cancer
References	[1]. Garske AL, et al. Chemical genetic strategy for targeting protein kinases based on covalent complementarity. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15046-52.