1391194-67-4

1391194-67-4 structure

Name: (2R)-Octyl-α-hydroxyglutarate
Chemical Name: (2R)-Octyl-α-hydroxyglutarate
CAS Number: 1391194-67-4
Molecular Formula: C₁₃H₂₄O₅
Molecular Weight: 260.327
Catalog: Research Areas Cancer
Create Date: 2018-01-13 20:41:29
Modify Date: 2024-01-10 15:54:42
(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a modified form of D-isomer 2-Hydroxyglutarate.

Name	(2R)-Octyl-α-hydroxyglutarate
Synonyms	(4R)-4-Hydroxy-5-(octyloxy)-5-oxopentanoic acid Pentanedioic acid, 2-hydroxy-, 1-octyl ester, (2R)- MFCD29045545

Description	(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a modified form of D-isomer 2-Hydroxyglutarate.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
In Vitro	Treatment of IDH1-WT HeLa cells with (2R)-Octyl-α-hydroxyglutarate, a modified form of 2-Hydroxyglutarate with high cellular uptake, results in a dose-dependent increase in DSBs in log-phase cells. It has been used to examine the contribution of D-2-Hydroxyglutarate to the oxidative mitochondrial processes of IDH1-mutated cancer cells[1].
References	[1]. Sulkowski PL, et al. 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologousrecombination and induces PARP inhibitor sensitivity. Sci Transl Med. 2017 Feb 1;9(375).