141335-10-6
141335-10-6 structure
- Name: LCB-2853
- Chemical Name: LCB-2853
- CAS Number: 141335-10-6
- Molecular Formula: C21H24ClNO4S
- Molecular Weight: 421.938
- Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
- Create Date: 2018-04-24 07:04:38
- Modify Date: 2024-02-11 06:57:31
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LCB-2853 is an antagonist of thromboxane A2 (TXA2) receptor, with antiplatelet and antithrombotic activities.
| Name | LCB-2853 |
|---|---|
| Synonyms |
(4-{[1-({[(4-Chlorophenyl)sulfonyl]amino}methyl)cyclopentyl]methyl}phenyl)acetic acid
Benzeneacetic acid, 4-[[1-[[[(4-chlorophenyl)sulfonyl]amino]methyl]cyclopentyl]methyl]- |
| Description | LCB-2853 is an antagonist of thromboxane A2 (TXA2) receptor, with antiplatelet and antithrombotic activities. |
|---|---|
| Related Catalog | |
| Target |
TXA2 Receptor |
| In Vivo | In dog coronary stenosis, LCB 2853 shows a very high efficacy with ED50 of 7.2 μg/kg. In rat venous thrombosis induced by combination of venous injury and blood stasis, perfused LCB 2853 decreases the weight of thrombi in a dose related manner with ED50 of 220 μg/kg/min[1]. In vivo, both against platelet aggregation and vasoconstriction, LCB 2853 shows an ED50 lower than 1 mg/kg i.v. in rat AA-induced thrombocytopenia or U 46619-induced hypertension (ED50 = 0.25 and 0.16 mg/kg) as well as in AA-induced sudden death in the mouse (ED50 = 0.44 mg/kg). The U 46619-induced bronchoconstriction is blocked after i.v. administration of LCB 2853 (ED50 = 18.4 μg/kg)[2]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 591.9±60.0 °C at 760 mmHg |
| Molecular Formula | C21H24ClNO4S |
| Molecular Weight | 421.938 |
| Flash Point | 311.8±32.9 °C |
| Exact Mass | 421.111450 |
| LogP | 5.26 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.602 |
| Storage condition | 2-8℃ |