1428569-85-0

1428569-85-0 structure

Name: GDC-0339
Chemical Name: GDC-0339
CAS Number: 1428569-85-0
Molecular Formula: C₂₀H₂₂F₃N₇OS
Molecular Weight: 465.495
Catalog: Signaling Pathways JAK/STAT Signaling Pim
Create Date: 2018-05-02 04:45:48
Modify Date: 2025-08-20 10:25:43
GDC-0339 is a Pim kinase inhibitor with IC50 of 43.6 nM for BaF3 PIM1.IC50 value: 43.6 nM (for BaF3 PIM1), 0.04 nM (Ki, for PIM1 LC-3K)Target: Pim

Name	GDC-0339
Synonyms	5-Amino-N-{5-[(4R,5R)-4-amino-5-fluoro-1-azepanyl]-1-methyl-1H-pyrazol-4-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide

Description	GDC-0339 is a Pim kinase inhibitor with IC50 of 43.6 nM for BaF3 PIM1.IC50 value: 43.6 nM (for BaF3 PIM1), 0.04 nM (Ki, for PIM1 LC-3K)Target: Pim
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> Pim Research Areas >> Cancer
Cell Assay	BaF3, a murine interleukin-3 dependent pro-B cell line, parental cells, BaF3 PIM 1 cells, BaF3 PIM2 cells, and MM1.S (multiple myeloma) cells are seeded at 2 k/well, 5 k/well, 5k/well, 10 k/well, respectively, in a 384-well plate, at 45 μL/well. GDC-0339 is added at 5 μL/well. BaF3 cells (parental and transfected) are incubated over night, while MM1.S cells are incubated for 72 hours at 37°C, 5% CO2, CELL TITER GLO Reagent is added at 50 μL/well, the plates are incubated for 30 minutes, and their luminescence read on an HT Analyst. IC50/EC50 values for GDC-0339 is calculated[1].