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1562338-42-4

1562338-42-4 structure
1562338-42-4 structure
  • Name: LMI070
  • Chemical Name: LMI070
  • CAS Number: 1562338-42-4
  • Molecular Formula: C22H27N5O2
  • Molecular Weight: 393.482
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
  • Create Date: 2018-10-16 06:39:36
  • Modify Date: 2024-01-07 10:57:36
  • LMI070 (Branaplam) is a highly potent, selective and orally active small molecule SMN2 splicing modulator.

Name LMI070
Synonyms branaplam
P12R69543A
Phenol, 5-(1H-pyrazol-4-yl)-2-[6-[(2,2,6,6-tetramethyl-4-piperidinyl)oxy]-3-pyridazinyl]-
5-(1H-Pyrazol-4-yl)-2-{6-[(2,2,6,6-tetramethyl-4-piperidinyl)oxy]-3-pyridazinyl}phenol
LMI070
Description LMI070 (Branaplam) is a highly potent, selective and orally active small molecule SMN2 splicing modulator.
Related Catalog
References

[1]. Palacino J, et al. SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice. Nat Chem Biol. 2015 Jul;11(7):511-517.

Density 1.2±0.1 g/cm3
Boiling Point 660.0±55.0 °C at 760 mmHg
Molecular Formula C22H27N5O2
Molecular Weight 393.482
Flash Point 353.0±31.5 °C
Exact Mass 393.216461
LogP 2.86
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.576
Storage condition -20℃