1638211-05-8

1638211-05-8 structure

Name: TH287 hydrochloride
Chemical Name: TH287 hydrochloride
CAS Number: 1638211-05-8
Molecular Formula: C₁₁H₁₁Cl₃N₄
Molecular Weight: 305.591
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2018-04-21 11:15:13
Modify Date: 2024-01-14 10:48:29
TH287 hydrochloride is a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM, less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.IC50 value: 0.8 nM [1]Target: MTH1 inhibitorTH287 is considered a new target for cancer therapy. TH287 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family. TH287 has been shown to selectively kill a variety of cancer cell lines, but is rapidly metablized, so not as useful for in vivo studies.

Name	TH287 hydrochloride
Synonyms	2,4-Pyrimidinediamine, 6-(2,3-dichlorophenyl)-N4-methyl-, hydrochloride (1:1) 6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine hydrochloride (1:1) TH287 (hydrochloride)

Description	TH287 hydrochloride is a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM, less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.IC50 value: 0.8 nM [1]Target: MTH1 inhibitorTH287 is considered a new target for cancer therapy. TH287 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family. TH287 has been shown to selectively kill a variety of cancer cell lines, but is rapidly metablized, so not as useful for in vivo studies.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Research Areas >> Cancer
References	[1]. Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21.