194098-25-4

194098-25-4 structure

Name	CP-409092
Synonyms	420WLS764W CP-409092 1H-Indole-3-carboxamide, 4,5,6,7-tetrahydro-N-[4-[(methylamino)methyl]phenyl]-4-oxo- N-{4-[(Methylamino)methyl]phenyl}-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide

Description	CP-409092 is a GABA(A) partial agonist, used for the treatment of anxiety.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease
In Vivo	The pharmacokinetics of CP-409,092 following single intravenous and oral doses of 4 and 15 mg/kg, respectively, are characterized by high clearance of 169+ or -18 mL/min/kg, a volume of distribution of 8.99+ or -1.46 L/kg, and an oral bioavailability of 2.9%+ or -3%. Following oral administration of 100 mg/kg [14C]CP-409,092, the total recovery is 89.1%+ or -3.2% for male rats and 89.3%+ or -0.58% for female rats[1].
References	[1]. Kamel A, et al. Metabolism, pharmacokinetics and excretion of the GABA(A) receptor partial agonist [(14)C]CP-409,092 in rats. Xenobiotica. 2010 Jun;40(6):400-14.