308362-25-6
308362-25-6 structure
- Name: Ridinilazole
- Chemical Name: Ridinilazole
- CAS Number: 308362-25-6
- Molecular Formula: C24H16N6
- Molecular Weight: 388.424
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2018-10-17 15:16:44
- Modify Date: 2024-01-10 23:50:09
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Ridinilazole is a novel antibacterial with MICs range of 0.06-0.25 µg/mL (MIC90=8 µg/mL) against C. difficile.
| Name | Ridinilazole |
|---|---|
| Synonyms |
10075
2,2'-Di(4-pyridinyl)-3H,3'H-5,5'-bibenzimidazole UNII-06DX01190R 6,6'-Bi-1H-benzimidazole, 2,2'-di-4-pyridinyl- Ridinilazole 06DX01190R |
| Description | Ridinilazole is a novel antibacterial with MICs range of 0.06-0.25 µg/mL (MIC90=8 µg/mL) against C. difficile. |
|---|---|
| Related Catalog | |
| Target |
MIC90: 8 µg/mL (C. difficile)[1] |
| In Vitro | Ridinilazole is a novel antibacterial that does not appear to act through the classical pathways associated with antibiotics, such as inhibition of cell wall, protein, lipid, RNA or DNA synthesis. Ridinilazole may impair cell division. Ridinilazole is bactericidal against C. difficile and exhibits a prolonged post-antibiotic effect. In susceptibility testing of 82 clinical isolates of C. difficile (including ribotype 027), Ridinilazole displays potent growth inhibition and has lower MICs [MIC range, 0.06-0.25 µg/mL; MIC for 90% of the organisms (MIC90), 0.125 µg/mL] than Metronidazole (MIC range, 0.125-8 µg/mL; MIC90, 8 µg/mL) or Vancomycin (MIC range, 0.5-4 µg/mL; MIC90, 2 µg/mL). Similarly, Ridinilazole is found to be more potent than Metronidazole or Vancomycin at inhibiting the growth of 50 ribotype-defined C. difficile strains. The activity of Ridinilazole against specific C. difficile ribotypes (including ribotypes 001, 002, 005, 014, 027, 054 and 106) is similar, with an MIC range of 0.06–0.5 µg/mL and an MIC90 of 0.125 µg/mL. In addition, Ridinilazole is more active against 11 ribotype 027 strains than either Metronidazole or Vancomycin[1]. |
| In Vivo | In a hamster model of CDI with a once-daily dosing regimen, Ridinilazole displays greater efficacy than Vancomycin both against non-epidemic and epidemic strains of C. difficile. Similar to the twice-daily dosing study, plasma levels of Ridinilazole are below the level of detection, whereas caecal Ridinilazole concentrations are well above the MIC, thus demonstrating the non-absorbable nature of Ridinilazole and minimal systemic exposure[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 774.9±70.0 °C at 760 mmHg |
| Molecular Formula | C24H16N6 |
| Molecular Weight | 388.424 |
| Flash Point | 352.4±28.6 °C |
| Exact Mass | 388.143646 |
| LogP | 3.51 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.764 |
| Storage condition | 2-8℃ |