745020-66-0

745020-66-0 structure

745020-66-0 structure

Name: NVX-207
Chemical Name: NVX-207
CAS Number: 745020-66-0
Molecular Formula: C₃₆H₅₉NO₆
Molecular Weight: 601.857
Catalog: Research Areas Cancer
Create Date: 2018-06-05 15:09:37
Modify Date: 2024-01-03 12:42:41
NVX-207 is a derivative of betulinic acid with anti-cancer activity.

Name	NVX-207
Synonyms	2-Amino-3-hydroxy-2-(hydroxymethyl)propyl (3β)-3-acetoxylup-20(29)-en-28-oate Lup-20(29)-en-28-oic acid, 3-(acetyloxy)-, 2-amino-3-hydroxy-2-(hydroxymethyl)propyl ester, (3β)-

Description	NVX-207 is a derivative of betulinic acid with anti-cancer activity.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
In Vitro	NVX-207 shows anti-tumour activity (mean IC50 = 3.5 μM) against various human and canine cell lines. NVX-207-induced apoptosis is associated with activation of the intrinsic apoptotic pathway via cleavage of caspases -9, -3, -7 and of poly (ADP-ribose) polymerase (PARP). NVX-207 induces cell death via apoptosis[1]. NVX-207 has a high cytotoxicity with IC50 values ranging from 7.6-8.5 µM, in the three analyzed malignant glioma cell lines. NVX-207 leads to PARP cleavage and to a decrease in Survivin expression levels under normoxic and hypoxic conditions. NVX-207 (20 µM) causes a significantly high rate of necrosis of glioma cell lines[2].
In Vivo	Intravenous application of NVX-207 in mice is well tolerated[1].
Cell Assay	Cytotoxic activities are evaluated using the Sulforhodamine-B (SRB) assay. Exponentially growing cells are seeded into 96-well plates at cell densities to prevent confluence for 96 h. After 24 h, the cells are treated using a dilution series of the compounds for 72 h under normoxic or hypoxic conditions. After treatment, the adherent cells are fixed using 10% TCA at 4°C for 1 h; the cells are washed with ice-cold water and are dyed using 100 µL of 4.4% SRB solution for 10 min. After staining, the plates are washed with 1% acetic acid and air-dried overnight. Three hundred microliters of 20 mM Tris base solution is added, and the absorbance is measured at 540 nm using a 96-well plate reader. The IC50 values indicate the concentrations of the compound that cause 50% cell inhibition. The data are obtained in three independent experiments.
References	[1]. Willmann M, et al. Characterization of NVX-207, a novel betulinic acid-derived anti-cancer compound. Eur J Clin Invest. 2009 May;39(5):384-94. [2]. Bache M, et al. Betulinic acid derivatives NVX-207 and B10 for treatment of glioblastoma--an in vitro study of cytotoxicity and radiosensitization. Int J Mol Sci. 2014 Oct 30;15(11):19777-90.

Density	1.1±0.1 g/cm3
Boiling Point	664.8±55.0 °C at 760 mmHg
Molecular Formula	C₃₆H₅₉NO₆
Molecular Weight	601.857
Flash Point	355.8±31.5 °C
Exact Mass	601.434265
LogP	9.76
Vapour Pressure	0.0±4.6 mmHg at 25°C
Index of Refraction	1.553
Storage condition	2-8℃