823218-99-1

823218-99-1 structure

Name: SN 2
Chemical Name: SN 2
CAS Number: 823218-99-1
Molecular Formula: C₁₇H₂₁NO
Molecular Weight: 255.355
Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
Create Date: 2018-05-04 12:15:04
Modify Date: 2024-01-02 23:09:38
SN 2 is a novel and potent activator of TRPML3 ion channel with EC50 of 1.8±0.13 μM.

Name	SN 2
Synonyms	5-Mesityl-3-oxa-4-azatricyclo[5.2.1.02,6]dec-4-ene 4,7-Methano-1,2-benzisoxazole, 3a,4,5,6,7,7a-hexahydro-3-(2,4,6-trimethylphenyl)- MFCD05739166 MFCD09266779

Description	SN 2 is a novel and potent activator of TRPML3 ion channel with EC50 of 1.8±0.13 μM.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Others
Target	EC50: 1.8±0.13 μM (TRPML3), >29.9 μM (TRPML1)[1]
In Vitro	The conductance of TRPML3 channels is estimate, when activated with 10 µM SN-2 is approximately 10 pS at −80 mV. TRPML3-expressing HEK293 cells are perfused with a series starting with compound alone (in SBS), with compound in ELS, and finally with ELS alone. Two representative compounds, SF-24 and SN-2, are tested. SF-24 is one of the least effective compounds, and SN-2 is one of the most active ones. SN-2 has a similar synergistic effect, also reaching up-to 10-fold enhancement of the combined response when compared with the individual responses, reaching average current densities of up to 3 nA/pF at −80 mV. Dominant negative TRPML3(D458K) is highly effective in eliminating SN-2-induced activity in epidermal melanocytes, suggesting that SN-2 activates a channel that is not responsive in presence of TRPML3(D458K). Such a dominant negative action might be attributed to potential heteromerization of TRPML3(D458K) with an SN-2-responsive channel[1].
References	[1]. Grimm C, et al. Small molecule activators of TRPML3. Chem Biol. 2010 Feb 26;17(2):135-48.